amyotrophic lateral sclerosis with laboratory abnormalities of uncertain significance: a brief review.

amyotrophic lateral sclerosis (als), the most common form of motor neuron disease, is a progressive and devastating disease involving both lower and upper motor neurons, typically following a relentless progression towards death. therefore, all efforts must be made by the clinician to exclude alternative and more treatable entities. als with laboratory abnormalities of uncertain significance is a subgroup of als that occurs in association with laboratory defined abnormalities that are of uncertain significance to the pathogenesis of als. the clinical utility of these abnormalities and what they ultimately mean in patients with als is discussed here, along with a review of the literature.